In 1924, Nobel Prize winner, Otto H. Warburg MD and physiologist, hypothesized that "Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar."
In 1953, Hans Krebs, a German-born British physician and biochemist, whom during his early career collaborated with Dr. Warbug in his laboratory, won the Nobel Prize in physiology for discovering the Kreb’s Cycle which is defined as a series of chemical reactions used by all aerobic organisms to generate energy through the oxidization of acetate derived from carbohydrates, fats and proteins into carbon dioxide. Today, Kreb’s scientific discovery is at the cornerstone of how modern medicine understands cellular metabolism.